Diamond Retinal 10

Menopause, which officially begins one year after your last period, can bring with it some noticeable changes to your skin. As hormone levels plummet, your skin can become dry, slack, and thin. In menopause, skin quickly loses collagen. With the right care, you can lessen these effects. Diamond Retinal 10 Serum is especially designed for ages 40+ that we call perimenapouse. Formulated with 0.1% pure Retinal to improve skin texture and uneven skin tone. Helps to minimize the appearance of fine lines and wrinkles. Minimizes the negative effects on the skin caused by hormonal changes during perimenopause and  menopause periods.

All skin types

Specially formulated with advanced liposomal delivery system to ensure stability and provide slow release of high-potency retinaldehyde to mazimize anti aging benefits and minimize irritation. 
Boosts collagen production to help diminish fine lines and wrinkles as tighten and firm the skin.
Reduces brown spots and brightens skin. Provides a more even skin tone. 
Softens and smooths rough skin texture.

Size 30 ml / 0.1 fl.oz.
pH 5.0-5.5

Aqua, Caprylic/Capric Triglyceride, Dipropylheptyl Carbonate, Glycerin, Glyceryl Stearate, Cetyl Stearyl Alcohol, Phospholipids, Niacinamide, Ascorbic Acid, 3-O-Ethyl Ascorbic Acid, Sodium Hyaluronate, Sodium Polyacrylate, Retinal, Phenoxyethanol, Squalane, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Butylene Glycol, Carbomer, Polysorbate 20, Xanthan Gum, Ethylhexylglycerin, Tocopherol

Aqua, Caprylic/Capric Triglyceride, Dipropylheptyl Carbonate, Glycerin, Glyceryl Stearate, Cetyl Stearyl Alcohol, Phospholipids, Niacinamide, Ascorbic Acid, 3-O-Ethyl Ascorbic Acid, Sodium Hyaluronate, Sodium Polyacrylate, Retinal, Phenoxyethanol, Squalane, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Butylene Glycol, Carbomer, Polysorbate 20, Xanthan Gum, Ethylhexylglycerin, Tocopherol

When to Use: PM only. Retinoic acid conversion is an overnight process — always follow with SPF 30 or higher the following morning.

Application Steps:

Cleanse and pat skin completely dry
Apply Cyrène Hyaluronic Acid Intensifier first — allow to absorb fully before proceeding
Dispense 3–4 drops onto fingertips
Press gently across the face and neck; avoid the immediate eye orbit and lip margin
Allow 60 seconds to absorb fully
Apply Cyrène CeraPep Barrier Support Moisturiser to seal

Frequency — Re-introduction Protocol Even For Experienced Users:

Weeks 1–2: Two to three applications per week
Weeks 3–4: Four to five applications per week
Week 5 onwards: Nightly, as tolerated

Pro Clinic Tip: At 0.1% retinal, retinoic acid receptor saturation at nightly use can cause a temporary plateau in visible results around weeks six to ten — a normal phase of the renewal cycle as skin adapts to sustained high-level retinoid activity. Maintain the protocol consistently through this phase; the structural collagen remodelling continues beneath the surface regardless of immediate visible change.

Next Step In The Series: Diamond Retinal 25 — Cyrène's professional-strength retinal formulation — is the final step for those requiring the highest available retinaldehyde concentration.

Pairs Best With

Cyrène CeraPep Barrier Support Moisturiser — Non-negotiable at this retinal strength. Apply as the final PM step to reinforce the stratum corneum and sustain barrier integrity through intensive retinoic acid-driven overnight turnover.
Cyrène Hyaluronic Acid Intensifier — Apply first on slightly damp skin. At 0.1% retinal, transepidermal water loss increases measurably; external hyaluronic acid layering compounds the formula's elevated internal hyaluronate content.
Cyrène Buffet Multi Peptide Complex Serum — Layer before Diamond Retinal 10 for a compounded collagen protocol. Matrixyl 3000 within both formulas drives collagen synthesis via complementary receptor and signalling pathways simultaneously.
Cyrène Invisible Physical Sunscreen SPF50 — Essential the following morning without exception. At 0.1% retinal, photosensitivity is at its highest within the consumer series; unprotected UV exposure actively reverses retinoic acid-driven renewal.

Do Not Combine In The Same Routine

AHAs & BHAs — At 0.1% retinal, combining exfoliating acids in the same routine risks significant barrier compromise and retinoid dermatitis. Strictly alternate evenings.
L-Ascorbic Acid Vitamin C — The formula's dual Vitamin C system provides sufficient antioxidant and brightening activity. Additional L-Ascorbic Acid at night is unnecessary.
Benzoyl Peroxide — Oxidises retinal immediately. Do not combine under any circumstances.
Other Retinoid Products — Do not layer additional retinol, retinal, or retinyl ester products in the same PM routine.

What percentage of retinal is actually effective for anti-ageing?
Clinical studies on retinaldehyde have demonstrated efficacy at concentrations as low as 0.01% — significantly lower than the concentrations required for comparable results with retinol. The therapeutic range for retinal in non-prescription skincare spans 0.01% to 0.1%, with each step up in concentration delivering faster retinoic acid conversion, more pronounced receptor activation, and accelerated visible results. Diamond Retinal 10 operates at 0.1% — the upper boundary of this range for consumer formulations — delivering a retinoic acid conversion rate that is clinically meaningful and approaches the activity level of prescription-adjacent retinoid treatments.

How does retinal work differently to retinol on the skin?
Both retinal and retinol are converted by the skin into retinoic acid — the form that directly activates retinoid receptors and drives cellular renewal. The critical difference is the number of conversion steps required. Retinol must undergo two enzymatic conversions to become retinoic acid; retinal requires only one. This means retinal reaches receptor-level activity faster, at lower absolute concentrations, and with greater consistency than retinol. In practical terms: visible results appear sooner, the effective dose is lower, and the formulation challenge of stabilising the active is significantly greater — which is why retinal products are less common and typically positioned at a higher price point than equivalent retinol products.

Can I use Diamond Retinal 10 if I have never used a retinoid before?
Diamond Retinal 10 is not recommended as a first retinoid. It is formulated for skin that has established consistent retinoid tolerance, ideally through progressive use of earlier steps in the Diamond Retinal series or through prior experience with high-strength retinol or prescription retinoid treatments. For those new to retinoids, Diamond Retinal 1 (0.01% retinal) is the correct entry point. Attempting to begin a retinoid protocol at 0.1% without prior tolerance-building significantly increases the risk of retinoid dermatitis — persistent redness, peeling, and barrier compromise that disrupts rather than advances skin health.

Is Diamond Retinal 10 safe to use long-term?
Yes. Retinaldehyde is one of the most extensively studied retinoid forms in both clinical and cosmetic research, with a well-established long-term safety profile at concentrations up to and including 0.1%. Consistent nightly use — always followed by broad-spectrum SPF the following morning — is the protocol that produces the most significant and sustained retinoic acid-driven skin improvements. Long-term retinoid use does not thin the skin; on the contrary, sustained retinoic acid receptor activation increases dermal collagen density over time, improving skin thickness and resilience.

How does Diamond Retinal 10 compare to Medik8 Crystal Retinal 10?
Both products deliver 0.1% retinaldehyde via encapsulated delivery systems designed for controlled, tolerability-optimised release, and both are positioned at the advanced end of the consumer retinal range. Cyrène Diamond Retinal 10 includes Matrixyl 3000 peptides — Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 — which provide independent, peptide-mediated collagen stimulation alongside the retinoic acid-driven renewal response. This active combination is not present in the Medik8 Crystal Retinal 10 formulation. Both are appropriate choices for experienced retinoid users operating at this concentration threshold.